Volume 14 No 2 (2022): International Journal of Early Childhood Special Education
Toll-Like Receptor 2 And 4 Polymorphisms in Asthmatic Children and Its Relation to Cardiac Function
Mohammed Sanad, Ahmed EL-Hewala, Heba M. ALhakim, Reham Hassan Anis
DOI: 10.9756/INT-JECSE/V14I2.200
Keywords: Asthma; Toll-Like Receptor; Cardiac Function; Children
Abstract
Bronchial asthma is a common chronic inflammatory disorder of the airways that results from both genetic and environmental factors and can affect cardiovascular system on the long run. Toll-like receptors (TLRs) are a class of proteins that recognize the microbial pathogen-associated molecular patterns in the environment and bridge the innate and acquired immune systems.TLR2 and TLR4 are believed to play an important role in the pathogenesis of asthma. Activated TLR2 and TLR4 can directly or indirectly affect the function of regulatory T cells, thus influencing the Th1/Th2 imbalance and reducing inflammatory responses so it is important to identify TLR2 and TLR4 polymorphisms in asthma and its relation to severity of asthma and cardiac function. Bronchial asthma affects many organs including the heart. The aim of this study to review the role of TLR2 and TLR4 polymorphisms in asthmatic children and its relation to cardiac function
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Volume 14 No 2 (2022): International Journal of Early Childhood Special EducationSection
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