Objective: to study the nature of renal hemodynamics in patients with severe complications of diabetic foot syndrome (ulcer, gangrene, amputation) associated with chronic kidney disease. Research material.95 patients were examined (prospectively) with type 2 diabetes with SDS with severe complications in the period 2021-2024 in the Department of Endocrinology, in the department of diabetic foot. All observed patients were divided into 4 groups: 1 gr. – 25 patients with SDS, complicated by ulcer, gangrene and amputation and combined with CKD of 4-5 stages on hemodialysis 2 gr. – 25 patients with SDS, complicated by ulcers, gangrene and amputation in combination with CKD of 4-5 stages without hemodialysis 3 gy – 20 patients with SDS, complicated by gangrene and amputation without CKD. 4 gy – 25 patients with SDS, without severe complications, with the initial stage of CKD. The control group consisted of 20 healthy individuals. The research methods are biochemical (bilirubin, direct, indirect, lipid spectrum, ALT, AST, PTI, coagulogram, blood sugar, glycated hemoglobin, urea, creatinine, GFR, wound pathogens, procalcitonin, interleukin - 6, vascular endothelial growth factor VEGF-A and instrumental: ECG, MRI of the feet, dopplerography of the main vessels legs, ultrasound of internal organs, fundus. The highest rates of fasting glycemia were observed in patients of group 2, that is, with SDS and CKD 4-5 ct without hemodialysis. Significantly lower hemoglobin values were also observed in this group of patients (p<0.001), glycated hemoglobin significantly higher values of urea, creatinine and GFR (p<0.001).All patients had significantly reduced HDL values (p<0.001) and total cholesterol (p<0.05). A study of renal hemodynamics found its violation in groups 1 and 2 of patients. Conclusion 1) Biochemical parameters were significantly impaired in patients of groups 1 and 2, that is, with SDS and CKD 4-5 ct on hemodialysis, which indicates the need for further studies in this group of patients. 2) There were significant differences between the indicators of dopplerography of the renal arteries in groups 1 and 2 in comparison with the data of the control group.

type 2 diabetes mellitus, diabetic foot syndrome, chronic renal failure, hemodialysis