The aim of the study was to study the relationship of the renal perfusion index with the systolic function of the heart in type 4 cardio-renal syndrome in patients with type 2 diabetes mellitus" Material and methods of research. The study, which was performed from January to May 2022, included 48 patients with type 2 diabetes mellitus and stage 1-3 CKD. (16 W, 32 M, age 50± 17 years, BMI 27.02± 3.44 kg/m2.) according to the study protocol. Hypertensive nephropathy (GT-CKD) treated 12 patients. None of the patients included in the study had detected heart failure. The control group consisted of 20 patients with DM2 without CHF and without CKD. Clinical and biochemical research methods were used in the study (glycemia, glycated hemoglobin, IRI, C-peptide, ALT, AST, bilirubin, urea, creatinine, PTI, hormonal studies (renin, angiotensin, aldosterone)as well as instrumental methods of examination-ultrasound of internal organs, ultrasonography with an assessment of the overall intensity of cortical perfusion of the kidneys and the index of renal perfusion (IRP), ECG, Echo-ECG, indicators of the quality of life of patients (questionnaire), as well as statistical methods. The results of the study. Analyzing the data of dopplerography of the heart and kidneys, we present for the first time the effect of systolic heart function on RI in patients with DM 2 with CKD. This makes it possible with the probability of early non-invasive detection of cardiac systolic pathology during kidney ultrasound, when high-quality ultrasound examination of heart structures is impossible (lack of methodology, pulmonary emphysema, obesity). Finally, it is likely that the assessment of RI may be useful for the early detection of cattle associated with a decrease in cardiac output [ 14 ]. Nevertheless, the applicability of RI for the diagnosis of early abnormalities of the cardioventricular axis requires further study. Conclusions. 1. In the group of patients with type 2 diabetes with CKD stage 1-3 without CHF, we detected changes in the Echo-ECG type of LV diastolic dysfunction of 1-2 degrees with a tendency to increase the average pressure in the pulmonary artery. 2. RI can be used as an independent marker for predicting the outcomes of the course of CKD in type 2 diabetes.

diabetes mellitus type 2, cardio-renal syndrome