Background: Postoperative pain, through diminished patient satisfaction and prolonged rehabilitation, may have a significant impact on patient recovery. While pain is inevitable part of post-operative period, it is relevant common to have insufficient pain control which can have profound consequences. Post-operative pain has been a continuous struggle for health care, despite guidance and recommendations from pain management societies. Total joint arthroplasty is currently a potential treatment for severe arthritis, although post-operative pain control remains a concern. This study will compare two analgesic techniques (epidural infiltration and extraosseous infiltration) in terms of analgesic impact (as measured by the VAS score), early motor activities, and pain relief period duration after total joint arthroplasty, as well as drug safety. Aim:Study the effect of extraosseous local infiltration of multimodal drug for post-operative pain management after total joint arthroplasty in lower limb. Objective: 1. To compare the effect of epidural analgesia versus multimodal drug cocktail for pain relief in post-operative period with help of VAS score 2. To study comfort of patients in terms of walking distance, hip and knee range of movements in postoperative period. Material and methods: • Adults coming to Department of orthopedics with advanced osteoarthritis of hip, knee and who will undergo arthroplasty surgery will be divided into 2 groups. Out of these 2 groups: one group will be given multimodal cocktail infiltration locally and other group will receive epidural analgesia. Expected Results: This study will help us determine the efficacy of extraosseous local infiltration of a multimodal medication cocktail for pain relief following total joint arthroplasty in the lower limb. After the study, final results will be determined

Post-operative pain, arthroplasty, local infiltration analgesia.