Research Article | Open Access
Role of S-Layer of Tannerella forsythia in virulence Potential of chronic and aggressive periodontitis Patients – A molecular study in central India
Dr. Ramniwas Kumawat , Dr. Pratima Dongre, Dr.Virendra singh, Dr. Renu
Pages: 3728-3734
Abstract
Background- Approximately 70% of the Indian adult population has at least one periodontal site with demonstrable gingival recession and bone loss. A consortium of three organisms denoted as the ‘red complex’ (Porphyromonas
gingivalis, Tannerella forsythia, and Treponema denticola) has the highest association with periodontal disease severity. Amongst them T. forsythia is a gram-negative, anaerobic bacterium. Its presence in subgingival flora has
been significantly associated with severe periodontal diseases. This bacterium has a suite of molecular determinants like S-layer associated proteins which could enable it to cause tissue damage and subvert the host immune response.
So, aim of this study was to detect the virulence potential of S-layer of T. forsythia in the sera of the periodontitis patients
Keywords
S-layer- surface layer, SDS-PAGE- Sodium dodecyl sulfate polyacrylamide gel electrophoresis, KdaKilodalton, CP-Chronic Periodontitis, AgP-Aggressive Periodontitis, HC- Healthy control Highlight’s of study: This study assesses S-layer a virulent factor of T.forsythia and it has role in pathogenesis in chronic as well as aggressive periodontitis patients of Indian population, which may be useful in the establishment of preventive and therapeutic strategies. Role of S-layer of Tannerella forsythia in virulence potential of chronic and aggressive Periodontitis patients- A molecular study in central india