Quorum sensing is the cell to cell communication mechanism in microorganism through signalling molecules. Pseudomonas aeruginosa is an opportunistic pathogenand well known for its nosocomial infection and multi-drug resistance (MDR).P. aeroginosa uses quorum sensing system to regulate their co-operative phenotypic behaviours like biofilm formation, virulence factor etc.,Las and Rhl are acyl homoserine lactone(AHL) based QS systems present in P.aerginosa and the Las system comprised of the transcriptional factor called LasR which can activate the expression of target virulence gene. Thus the pathogenic activity of in P.aerginosacan be repressed by restraining the target protein, LasR with suitable bioactive molecules. In the present study, bioactive compounds from various natural food sources have been selected and tested against LasR protein using bioinformatics tools for its quorum quenching activity. In silico analysis gave prominent results for thirteen compounds out of 25 compounds tested with best docking score. These selected for compounds can be suggested for in vitro and in vivo studies and could be used for QSI based drugs against P.aerginosa infections.

Quorum Sensing Inhibitors (QSI), P. aerginosa, Nosocomial infection, Molecular Docking, Bioactive compounds.