Research Article | Open Access
Electrical resistance during blood coagulation – A pilot study
Hemashree L , Dr. Vani Krishna Murthy, Dr. Srinivasa Murthy Doreswamy
Pages: 1668-1674
Abstract
Introduction: Deranged blood coagulation leads to uncontrolled bleeding and blood loss resulting in hypovolemic shock.Identification of such altered coagulation state is of at most importance for sick patients receiving intensive care treatment. Currently, laboratories used elaborative enzymatic methods for identifying changes in mechanical or optical properties of plasma and not the whole blood. These tests typically take about an hour to be reported. Other point of care coagulometer using viscoelastic principle applied to whole blood is too expensive.Several studies have been conducted in a non-clinical environment and have shown the change in the electrical properties of the blood during the process of coagulation. The advantages of using electrical principles include a small form factor, ubiquity of use and not needing technical expertise for use.Method: A purpose-built device studied under various clinical conditions could serve as a proof of concept for the further development of precise medical-grade devices for clinical use. A purpose-built device working on the potential divider principle and a gold-plated electrode was tested in this pilot study using 32 clinical samples.
Result: The average difference between the electrical resistance before and after coagulation was 5178 ohms which were statistically significant.The median (interquartile range) of time taken to the first peak of uncoagulated blood
was 565 (470 – 594) seconds. The time is taken after coagulation was 333 (73 – 558) seconds. The median difference was not statistically significant with a p-value of 0.149. The rate of ascent to the first peak denoted as dr/dt of uncoagulated blood was 34 (29 – 60) ohms/sec. The rate of ascent after coagulation was 45 (40 - 82) ohms/sec. The median difference was statistically significant with a p-value of 0.039.
Conclusion: Coagulation status can be assessed using the electrical properties of the blood
Keywords
Human blood, electrical resistance, coagulation