Vitamin B4 (folate) is a naturally occurring vitamin. Folic acid helps healthy RBCs. It helps make DNA and other genetic material. These seeds are high in folic acid. Folic acid is crucial in labour. Consumption of edible seeds, notably sunflower seeds, reduces the risk of coronary heart disease, high cholesterol, and hypertension. This review focuses on extraction of folic acid from sunflower seed and its impact on fetal growth. From sun flower seed, folic acid is extracted primarily via High Power Liquid Chromatography. Folate are degraded while cooking (thermal degradation), the sutiable technology for extraction of folic acid is microbial growth method and High power Liquid chromatography. L- methylfolate (l5 Methyltetrahydrofolate) is an important micronutrient form of folate that are dissolved in plasma and participate in biological activities. Methylene – tetra hydrofolatereductase (MTHFR) enzyme serves a key function for almost all biological processes that involve the metabolism of methionine and folic acid. lmethylfolate supplementation is preferred , rather than folic acid to decrease folate related pathological diseases

Folic acid, Dietary supplements, Sunflower seeds, Pregnancy, Chromatography, Methionine, Methyl folate, NTDs, Homocysteine .