Cancer is a serious disease in which cancer cells divide out of control, resulting in uncontrolled growth and spread.LIF (laser fluorescence spectroscopy) as a potential cancer diagnostic technique. As a non-invasive tool for cancer diagnostics, a complete analytical investigation of an in vitro fiber-optic-based compact sensor LIF for point monitoring of tissue auto fluorescence is provided. The effects of two key sensor design parameters, excitationcollecting geometry and excitation wavelength, on tissue spontaneous fluorescence response and malignancy resolution, were studied. An attempt was made to establish the best sensor configuration for developing a diagnostic technique that would improve the accuracy of fluorescence cancer diagnosis by enhancing a tiny spectral difference.

Laser-induced fluorescent spectroscopy, Auto-fluorescence, cancer diagnosis