Banana is one of the oldest fruit crops domesticated by humans, delicious test and nutritional value has made it one of the most economically important plants in the globe. In this work, banana peels and pulps were extracted with two organic solvents as well as water. The aim of this study is to identify the cytotoxic effects. Musa sapientum ,it is less cytotoxic effect because most number of nauplius are alive.In 5 μL 9 nauplii was alive, in 10μL 9 nauplii were alive, in 20μL,in 40μ 8 nauplii were alive, in 80 μL, 7 nauplii were alive,control 10 nauplii were alive. Targeting tumor angiogenesis using natural antiangiogenic medicines that prevent the formation of new blood vessels that feed nutrients and oxygen to the tumor provides a viable therapeutic strategy against tumor development and metastasis, comparatively my study says about the toxicity of the nauplius in banana stem. The nauplius are alive so it is concluded that the banana stem is less toxic

Cytotoxic, nauplius, less toxicity.