Berberine, a benzylisoquinoline alkaloid found in a variety of medicinal plants, has a wide range of pharmacological characteristics. Berberine has diverse inhibitory effects on different bacteria, however one element of its selectivity by using insilico methods is that the impact is very good with the maximal inhibitory concentration for Eikenella corrodens. Materials and Methods: The STITCHv5.0 pipeline was primarily used for identifying drug-protein interactions; VirulentPred and VICMPred were used for elucidating the virulence property and functional class of the proteins. Results: Berberine interacts with proteins includes in cellular processes, metabolism, and pathogenicity, according to research. The pathogenic proteins attacked by the medications were found in the cytoplasm, which would increase the potency of drug as antibacterial activity Conclusion: A thorough understanding of the interactions between these medications and their antibacterial agents would increase the list of advantages these treatments have in therapeutic situations. To validate the true interactions between medicines and pathogen protein repertoires, more in vitro study on a wide spectrum of infections is required.

Berberine, Bacteria, Pathogenicity, Virulence