Hemophagocytic Lymphohistiocytosis(HLH) is the second major alarm in infections. HLH is due to hyper-immune activity, leading to a variety of Hemato-immunological abnormalities. The disease can be fatal if left untreated. We report a 42-year-old male who has been admitted in our teritiary hospital with presenting complaints of loose stools,fever, and shortness of breath. The blood investigations showed a decline in cell count with pancytopenia, Hyperferritinemia, Hypofibrinogenemia, and hypertriglyceridemia. Blood culture revealed Salmonella typhyi growth. On overt exclusion of further possibilities, we made a diagnosis of HLH in accordance with HLH-2004 diagnostic criteria. This patient responded well with the traditional antibiotics, corticosteroids and on supportive management. There by we discuss the clinical course of this Hemato immunological condition and strive to raise the awareness of complications like secondary Hemophagocytic Lymphohistiocytosis caused by common diseases, such as a typhoid fever.

Hemophagocytic Lymphohistiocytosis, Salmonella Typhi, Hyperferritinemia, Hypofibrinogenemia, Hypertriglyceridemia