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Research Article | Open Access
Volume 14 2022 | None
A Comparative Study of Topical 3 % Tranexamic Acid Loaded Chitosan Microparticles Versus Triple Combination Kligman’s Therapy for the Treatment of Melasma
Amany Abdel Rahman Nassar ,Khaled Mohamed Gharib, Basma M. Abdel-Azim
Pages: 786-796
Abstract
Objective: Melasma is a common dermatological conditionthat may be presents a great therapeutic challenge to treat.Strict of regural sunscreenuse and topical bleaching cream combined with other treatment modailities, as laser or chemical peels have been shown mimimal improvements.Topical tranexamic acid (TA) recived a great atention as a newtreatmentmodality for melasma. The specific aim of the present study was to evaluate the efficacy of TA 3 % loaded chitosan microparticles (TA-CsMPs) and comparedwith Kligman’s formula. Methods:Total 24 females of melasma who met the requirement of inclusion criteria were included in our nonrandomized controlled study. Based in treatment regemine, they were classified in 2 categories. Category (I)females advised topical 3 % TA-Cs microgel twice daily, while category (II)wasreceived Kligman regimen once daily at night. Using a modified Melasma Area Severity Index (m-MASI) score,females were clinically evaluated once weekely for 6 weeks and followed up for 3 more months after treatment completion. Results: Dermal type of melasma, with lateral or centro-facial pattern of distribution and Fitzkpatrick type III was found mostly in patients. The m-MASI score was significantly lower in comparison to the baseline (p <0.05)in both investigatedcategories. Besideto the adversereaction as redness, irritation, orburningassociated with topical Kligmanformula, TA-CsMPs regimen has superior efficacy and safety in melasma treatment. Conclusion: Takentogether, our current outcomesdemonstrated thattopical 3% TA-CsMPs is an innovative,effective, and could be a potentially promising safe alternativewith good patient acceptance for melasma treatment
Keywords
Melasma, Tranexamic acid, Chitosan microparticles, MASI score
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